Endocrine Abstracts

Background: Patients with secondary adrenal insufficiency have an excess mortality. Data concerning the influence of the glucocorticoid replacement regime on mortality is sparse.Objective: To investigate if the total daily dose of glucocorticoid replacement has an effect on mortality in patients with non-functioning pituitary adenoma (NFPA).Method: Patients with NFPA treated for hypopituitarism in the western region of Sweden were ...

Introduction: Craniopharyngiomas are benign tumors in the suprasellar region that have encouraging survival rates between 77-93%. Unfortunately, long-term sequelae are frequent, resulting in excessive endocrine and metabolic morbidity, including premature cardiovascular disease and reduced bone health.Objective: To determine the prevalence of unfavorable body composition and low bone mineral density (BMD) in patients with craniopharyngioma.<p class="...

Objective: Craniopharyngioma (CP) is a benign tumor of the sellar/hypothalamic region. It is associated with endocrinopathies, which may potentially impair bone health. Our objective was to determine bone health status in CP patients.Methods: In this retrospective study, Dutch/Swedish CP patients were included if data was available on fractures, bone mineral density (BMD) (T/Z-score), or final height (age >18 years). Data is presented as mean±<s...

Introduction: Craniopharyngioma (CP) is a benign tumor of the sellar/hypothalamic region. It is associated with excess mortality, obesity and endocrinopathies. These endocrinopathies may influence bone health, and increase the risk of fractures.Methods: In this retrospective study, Dutch/Swedish patients with CP were included if data was available on final height (at age >18 years) or DXA-scan results. Information from the first and last DXA-scans we...

Introduction: Patients with craniopharyngioma (CP) suffer from pituitary deficiencies and hypothalamic damage, resulting in obesity and impaired bone health. Little is known about long-term changes in body composition and bone mineral density (BMD).Methods: Dutch and Swedish patients were included in this retrospective longitudinal study if they had DXA-scan (body composition/BMD) data available at age of 18 years or older. Linear regression modelswerees...